A doctor explains treatment options to a depressive patient. © Peera/stock.adobe.com
A doctor explains treatment options to a depressive patient. © Peera/stock.adobe.com
How can optimized expectations help with internet-based interventions for depression?
Depression is one of the most common mental illnesses worldwide, with up to 20 percent of people being affected during their lifetime. It places a huge burden on the sufferer, often leads to a reduced earning capacity, and has enormous social costs. Despite the existence of effective treatment options in the form of antidepressant medication and psychotherapy, depression remains untreated in a large number of cases. Sufferers often fear being stigmatized by the diagnosis and worry about side effects. Moreover, accessing psychotherapy is often difficult. This is where internet-based interventions can help: In many cases, these self-help materials work just as well as psychotherapy. What is more, they are low-threshold, flexible, inexpensive, and can even be individualized.
Negative expectations are common in depression – and put a strain on therapy
Our aim in Project A16 is to show how internet-based interventions can be substantially improved even more. To help us, we are drawing on our findings from the first funding period of our Collaborative Research Centre, in which we investigated the illness beliefs of patients with depression and how these beliefs affect treatment expectations and treatment success. Many sufferers develop a fatalistic view of their illness (‘I'm sick, there's nothing we can do’), are sceptical about treatments (‘Nothing will help me anyway’), and stop believing that they can do something about their depression themselves (‘I can't do it anyway’). Such negative beliefs can significantly impair the effectiveness of both antidepressants and psychotherapies, and can lead patients to discontinue their treatment.
However, beliefs are not unchangeable. In Project A16, our research has already shown that empathic communication by the therapist and meaningful explanations of the illness and the planned therapy can help to improve patients’ treatment expectations, consequently leading to greater treatment success.
Can optimized self-help materials lead to more successful therapy?
In the second funding period of Project A16, we are investigating how this approach can also make internet-based interventions more successful. Can treatment expectations be improved through self-help materials in patients with depression? Does this actually make therapy more successful? And how do expectations change in interaction with other factors, such as previous experiences, the severity of depressive symptoms, or discussions with experts? Project A16 wants to use the answers to these questions to significantly improve treatment options for depression in the coming years.
Brose, A., Heinrich, M., Bohn, J., Kampisiou, C., Zagorscak, P., & Knaevelsrud, C. (2023). Sequencing effects of behavioral activation and cognitive restructuring in an Internet-based intervention for depressed adults are negligible: Results from a randomized controlled trial. Journal of Consulting and Clinical Psychology, No Pagination Specified-No Pagination Specified. https://doi.org/10.1037/ccp0000789
Petrie, K. J., & Rief, W. (2019). Psychobiological Mechanisms of Placebo and Nocebo Effects: Pathways to Improve Treatments and Reduce Side Effects. Annual Review of Psychology, 70(1), 599–625. https://doi.org/10.1146/annurev-psych-010418-102907
Rief, W., Sperl, M. F. J., Braun-Koch, K., Khosrowtaj, Z., Kirchner, L., Schäfer, L., Schwarting, R. K. W., Teige-Mocigemba, S., & Panitz, C. (2022). Using expectation violation models to improve the outcome of psychological treatments. Clinical Psychology Review, 102212. https://doi.org/10.1016/j.cpr.2022.102212
Zagorscak, P., Heinrich, M., Sommer, D., Wagner, B., & Knaevelsrud, C. (2018). Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial. Psychotherapy and Psychosomatics, 87(1), 32–45. https://doi.org/10.1159/000481515
In close cooperation with these projects
How do expectations control our emotions - and what does attention have to do with it?
Prof. Dr. Stefanie Brassen
Do positive expectations improve the effect of antidepressants?
Prof. Dr. Tilo Kircher
PD Dr. Irina Falkenberg
This project has been completed.
Less worry, more optimism: Can antidepressant treatments be improved in real time?
Prof. Dr. Yvonne Nestoriuc
Prof. Dr. Winfried Rief
Project Lead
Prof. Dr. Winfried Rief
Psychologist, Psychological Psychotherapist

Prof. Dr. Christine Knaevelsrud
Psychologist, Psychological Psychotherapist
Team
Dr. Marcel Wilhelm
Postdoc, Psychologist, Psychological Psychotherapist, Emerging PI
Dr. Carmen Schäuffele
Postdoc, Psychologist, Psychological Psychotherapist, Emerging PI
Dr. Stephanie Häring
Postdoc, Psychologist, Psychological Psychotherapist i.e.
Dr. Pavle Zagorscak
Postdoc, Psychologist
Dr. Frauke Weiß
Clinician Scientist, Psychological Psychotherapist
Dr. Christina Kampisiou
Clinician Scientist, Psychological Psychotherapist
Sebastian Burchert
Psychologist
Liv Caro Henrich
PhD student, Psychologist, Psychological Psychotherapist in training
Philipp Lange
PhD student, Psychologist, Psychological Psychotherapist in training