Can migraine symptoms be relieved by patients knowingly taking tablets without an active ingredient?

Patients knowingly taking tablets without an active ingredient regularly for 12 weeks – can that really relieve the pain and physical impairment associated with migraine? That is the question this study aims to answer. In addition to their existing treatment, half of the patients will receive placebo tablets. We know from other pain disorders that placebos can relieve symptoms, even when patients know that they are not taking real medication, but there has been little research into which other factors, such as stress responses, genetics and brain responses, have an influence. This information would help to provide more personalised pain therapy.