Chronic back pain is the second most common cause of incapacity to work in Germany. © iStock.com/Wavebreakmedia
Chronic back pain is the second most common cause of incapacity to work in Germany. © iStock.com/Wavebreakmedia
Will that help me too? Positive treatment expectations through observation in patients with back pain
Positive expectations of a treatment can influence the sensation of pain and the efficacy of medication. But how can we selectively control patient expectations? Early studies indicate that simply observing successfully treated patients has a positive effect on one's own treatment expectations and changes the sensation of pain. This project will investigate this in patients with chronic back pain, with the long-term objective of improving treatment outcomes and reducing the use of medication.
Optimisation of treatment expectations in patients with chronic back pain through observation of others
This project will systematically vary patient expectations of treatment by showing them a positive or neutral treatment outcome in other patients. The effect of this expectation modulation on treatment outcome will be studied using analgesics or open-label placebos. In order to obtain both clinical and mechanistic data, the two factors – expectation and treatment – will be fully crossed. This will enable us to investigate the potential interaction effects of expectation and pharmacological analgesia.
Recommended reading:
Schmitz J, Müller M, Stork J, Eichler I, Zöllner C, Flor H, Klinger R (2019) Positive Treatment Expectancies Reduce Clinical Pain and Perceived Limitations in Movement Ability Despite Increased Experimental Pain: A Randomized Controlled Trial on Sham Opioid Infusion in Patients with Chronic Back Pain. Psychother Psychosom 88(4):203-214. PubMed
Klinger R, Matter N, Kothe R, Dahme B, Hofmann U, Krug F (2010) Unconditioned and Conditioned Muscular Responses in Patients with Chronic Back Pain and Chronic Tension-Type Headaches and in Healthy Controls. Pain 150 66-74. PubMed
Christiansen S, Oettingen G, Dahme B, Klinger R (2010) A short goal-pursuit intervention to improve physical capacity: A randomized clinical trial in chronic back pain patients. Pain 149 (3), 444-452. PubMed
In close cooperation with these projects
Where can expectations and treatment of pain be seen in the brain?
Prof. Dr. Christian Büchel
How does the prefrontal cortex process expectations of pain?
Prof. Dr. Michael Rose
How does our brain influence visceral pain?
Prof. Dr. Sigrid Elsenbruch
PD Dr. Julian Kleine-Borgmann
Do positive expectations improve the effect of antidepressants?
Prof. Dr. Tilo Kircher
PD Dr. Irina Falkenberg
Expectation-induced improvement in the treatment outcome of psoriasis patients in terms of pain, itching and quality of life.
Prof. Dr. Manfred Schedlowski
Dr. Wiebke Sondermann
Can migraine symptoms be relieved by patients knowingly taking tablets without an active ingredient?
Prof. Dr. Ulrike Bingel
Dr. Julian Kleine-Borgmann
Dr. Katharina Schmidt
Project Lead
PD Dr. Regine Klinger
Psychologist
Prof. Dr. Sigrid Elsenbruch
Psychologist
Team
Julia Stuhlreyer
Postdoc, Psychologist
Marie Schwartz
Postdoc, Psychologist
Dr. Johannes Wessels
Clinician Scientist