Individual perception of pain is a critical factor for millions of patients with irritable bowel syndrome. © kei907/stock.adobe.com
How does our brain influence visceral pain?
How do patients with irritable bowel syndrome perceive signals from the bowel and visceral pain compared to somatic pain? And how is this influenced by psychological factors, particularly negative expectations? These are important research questions, the answers to which could also be helpful for other chronic pain syndromes.
Effects of negative expectations on visceroception and visceral pain
This project investigates the effect of negative expectations on visceroception and visceral pain in healthy participants and patients with irritable bowel syndrome (IBS) as well as the extent to which these effects apply to another pain modality (somatic pain). Using an established, clinically relevant tonic pain model to deliver translational research, it will focus on the modulating role of stress and affective comorbidity, as these are factors that characterise patients with IBS and other chronic pain disorders.
Benson S, Siebert C, Koenen LR, Engler H, Kleine-Borgmann J, Bingel U, Icenhour A, Elsenbruch S (2019) Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: A randomized-controlled study in healthy men and women. Pain 160(8):1719-1728. PubMed
Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER (2010) Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut 59:489-95. PubMed
Elsenbruch S, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski ER (2010) Altered emotional modulation of the neural response to visceral stimuli in irritable bowel syndrome. Gastroenterology 139:1310-1319. PubMed
Schmid J, Theysohn N, Gaß F, Benson S, Gramsch C, Forsting M, Gizewski ER, Elsenbruch S (2013) Neural mechanisms mediating positive and negative treatment expectations in visceral pain: a functional magnetic resonance imaging study on placebo and nocebo effects in healthy volunteers. Pain 154:2372-2380. PubMed
In close cooperation with these projects
Prof. Dr. Sigrid Elsenbruch
Dr. Laura Ricarda Lanters
Dr. Rossitza Draganova
Dr. Jana Aulenkamp
Medial student, Paramedic